Study: People worldwide living longer, but sicker


LONDON (AP) — Nearly everywhere around the world, people are living longer and fewer children are dying. But increasingly, people are grappling with the diseases and disabilities of modern life, according to the most expansive global look so far at life expectancy and the biggest health threats.


The last comprehensive study was in 1990 and the top health problem then was the death of children under 5 — more than 10 million each year. Since then, campaigns to vaccinate kids against diseases like polio and measles have reduced the number of children dying to about 7 million.


Malnutrition was once the main health threat for children. Now, everywhere except Africa, they are much more likely to overeat than to starve.


With more children surviving, chronic illnesses and disabilities that strike later in life are taking a bigger toll, the research said. High blood pressure has become the leading health risk worldwide, followed by smoking and alcohol.


"The biggest contributor to the global health burden isn't premature (deaths), but chronic diseases, injuries, mental health conditions and all the bone and joint diseases," said one of the study leaders, Christopher Murray, director of the Institute of Health Metrics and Evaluation at the University of Washington.


In developed countries, such conditions now account for more than half of the health problems, fueled by an aging population. While life expectancy is climbing nearly everywhere, so too are the number of years people will live with things like vision or hearing loss and mental health issues like depression.


The research appears in seven papers published online Thursday by the journal Lancet. More than 480 researchers in 50 countries gathered data up to 2010 from surveys, censuses and past studies. They used statistical modeling to fill in the gaps for countries with little information. The series was mainly paid for by the Bill & Melinda Gates Foundation.


As in 1990, Japan topped the life expectancy list in 2010, with 79 for men and 86 for women. In the U.S. that year, life expectancy for men was 76 and for women, 81.


The research found wide variations in what's killing people around the world. Some of the most striking findings highlighted by the researchers: — Homicide is the No. 3 killer of men in Latin America; it ranks 20th worldwide. In the U.S., it is the 21st cause of death in men, and in Western Europe, 57th.


— While suicide ranks globally as the 21st leading killer, it is as high as the ninth top cause of death in women across Asia's "suicide belt," from India to China. Suicide ranks 14th in North America and 15th in Western Europe.


— In people aged 15-49, diabetes is a bigger killer in Africa than in Western Europe (8.8 deaths versus 1 death per 100,000).


— Central and Southeast Asia have the highest rates of fatal stroke in young adults at about 15 cases per 100,000 deaths. In North America, the rate is about 3 per 100,000.


Globally, heart disease and stroke remain the top killers. Reflecting an older population, lung cancer moved to the 5th cause of death globally, while other cancers including those of the liver, stomach and colon are also in the top 20. AIDS jumped from the 35th cause of death in 1990 to the sixth leading cause two decades later.


While chronic diseases are killing more people nearly everywhere, the overall trend is the opposite in Africa, where illnesses like AIDS, malaria and tuberculosis are still major threats. And experts warn again shifting too much of the focus away from those ailments.


"It's the nature of infectious disease epidemics that if you turn away from them, they will crop right back up," said Jennifer Cohn, a medical coordinator at Doctors Without Borders.


Still, she acknowledged the need to address the surge of other health problems across Africa. Cohn said the agency was considering ways to treat things like heart disease and diabetes. "The way we treat HIV could be a good model for chronic care," she said.


Others said more concrete information is needed before making any big changes to public health policies.


"We have to take this data with some grains of salt," said Sandy Cairncross, an epidemiologist at the London School of Hygiene and Tropical Medicine.


He said the information in some of the Lancet research was too thin and didn't fully consider all the relevant health risk factors.


"We're getting a better picture, but it's still incomplete," he said.


___


Online:


www.lancet.com


http://healthmetricsandevaluation.org


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'Evil' actor killed college students, girlfriend says




A woman authorities say helped her then-fiance after he allegedly killed two people said at a news conference Tuesday night that she is "completely innocent."


Rachel Mae Buffett, 25, addressed the media at her brother's Long
Beach wine bar flanked by her brothers, sister and mother. She declared
her innocence and vowed to assist Costa Mesa police in their ongoing
investigation into the May 2010 killings of two Orange Coast College
students.


"I will meet them anywhere, anytime," Buffett said. "I'm very compliant."


Police and prosecutors have said that Buffett helped her then-fiance
Daniel Patrick Wozniak, 28, after he killed Samuel Herr, 26,
his neighbor in the Camden Martinique apartments, and Herr's friend and
tutor Juri "Julie" Kibuishi, 23. Authorities say Buffett lied to police
after the slayings, telling police Herr had family problems when he did not.


Authorities said that Herr was killed at a Los Alamitos military base and later dismembered,
and that Kibuishi was killed at Herr's apartment, her body
positioned in such a way to make authorities believe she had been sexually
assaulted.


In a previous interview with the Daily Pilot from jail, Buffett described both victims as "so sweet" and said she continues to grieve for them.


"I'm really sorry such evil has occurred," Buffett said.


In addressing the charges facing her former fiance, Buffett said: "I'm glad that I don't have to do the sentencing.


"I think that they're very justified in going for the death penalty," Buffett said.


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-- Lauren Williams, Times Community News



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IHT Rendezvous: Gay Marriage Fight Intensifies in Britain and France

LONDON — The pragmatic Dutch should be forgiven for wondering what all the fuss is about.

A decade after the Netherlands legalized marriage for same-sex couples with a minimum of brouhaha, the issue has spurred a fierce and emotional debate in two other European countries, France and Britain.

The disputes focus on plans by the Socialist government in France and the Conservative-led government in Britain to introduce legislation next year that would allow same-sex marriage.

The British government announced its proposals on Tuesday with a compromise that left both sides of the debate unhappy.

The proposed law specifically excludes the established Anglican churches of England and Wales by forbidding them from marrying same-sex couples, while other faith groups such as Quakers and liberal Reform Jews would be allowed to opt into the system.

That is intended to protect a reluctant Anglican Church from being forced into performing gay marriage ceremonies. But it added to what gay and equal rights activists described as the muddle surrounding law reform.

Peter Tatchell, a veteran gay rights activist, told Pink News that the Conservative proposals actually discriminated against heterosexual couples by denying them the right to a civil partnership, the so-called “marriage lite” that has been available to gay couples in Britain since 2004.

The proposed British compromise looked unlikely to quell opposition within Prime Minister David Cameron’s Conservative Party from those who reject the concept of same-sex marriage on religious, social or moral grounds.

The right-wing United Kingdom Independence Party has threatened to exploit divisions which it said threatened to rip apart the Conservatives’ traditional rural base.

“We feel the prime minister’s proposals will present an affront to millions of people in this country for whom this will be the final straw,” Nigel Farage, the UKIP leader, told The Guardian.

Mr. Farage may be exaggerating the extent of opposition in a country where opinion polls show a majority in favor of allowing same-sex marriage. But, as in France, the opposition is certainly noisy.

Anti-gay marriage groups staged demonstrations across France in October and November that attracted an estimated 100,000 people. The ruling Socialist Party has decided to fight back by throwing its support behind a counter-demonstration due to take place in Paris this weekend.

Romain Burrell, a journalist for a French gay magazine, wrote in The Guardian, “It’s quite simple. The ongoing same-sex marriage debate sparked a renewed wave of homophobia in France.”

He lamented that the opposition conservative U.M.P. had thrown its weight behind the anti-gay marriage campaign.

The Netherlands, meanwhile, appears to have survived unscathed from 11 years of same-sex marriage.

My colleague Celestine Bohlen, in a report from Amsterdam last week, cited polls that showed support for same-sex marriage increased by 20 points to 82 percent in the five years after the Dutch law was introduced.

As Celestine wrote, “Gay or straight, married, divorced, single or cohabiting, the Dutch — like many other Europeans — have been quietly rearranging their family structures over the past decade.”

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‘The Hobbit’: Like One Bad Video Game






Perhaps the most exciting thing about Peter Jackson‘s landmark, blockbuster Lord of the Rings films was that they made fans, through a combination of stunning landscapes and intricate special effects and soaring music and dramatic spectacle, feel as though we were seeing an almost impossible elevation of the potential size and scope of movies. Here was a rich, dense, sprawling series of films that thundered like myths, that were breathtaking in their realization of some pretty huge ambitions. Sure, they were massive corporate projects that earned lots of people millions of dollars, but to the regular moviegoer they were feats that proved the majesty of the movies, the potential to tell enthralling stories that also played like art. And so it’s hugely disappointing, if not all that surprising, that Jackson’s first foray back into the land of Middle Earth, The Hobbit: An Unexpected Journey, is such a sullenly, basely commercial and junky affair, a movie that feels not crafted with Jackson’s seemingly divine inspiration but by the hands of studio executives. Perhaps the reason that Warner Bros. is forgoing the usual console video-game tie-ins for simple mobile games is because the damn movie already looks like a video game, and not a very fun one at that.


RELATED: ‘The Hobbit’ Trailer Needs to Get Out of the Shire






The Lord of the Rings series succeeded aesthetically because it was such an elegant, painting-like wonder to behold. The textures and palettes all had the look of a particularly vibrant illustrated story book, the kind of immersive vision that exists somewhere between imagination and the real world. For The Hobbit, though, Jackson chose to film at a high frame rate and with Real 3D technology in mind — because 3D movies are doing well these days and, hell, doesn’t hurt that the tickets cost more — but the results are frequently hideous. Those among us who have bought shiny new flatscreen TVs over the past few years are likely familiar with the dreaded “Soap Opera Effect,” which turns what should be stunning, glossy images into cheap-looking messes, all strange movement and lighting, like any network soap or cheap British show. (Think Children of Men looking like Torchwood.) It’s the problem of technology over-thinking or over-performing, and it is on startling, gruesome display in The Hobbit. When you’re wearing the 3D glasses (and admittedly sitting a little off to the side), this hugely expensive movie looks like it was shot on a nice handheld digital camera on the cheap. Actors stand in strange contrast to the digital backgrounds behind them, motion looks too slick or unnatural. Gone are the somber vistas and rugged terrain, replaced by eye-aching shine and plastic-y smoothness. The most special effects-heavy sequences look very much like the non-playable parts of modern video games — the exposition bits that can amp up the graphics a bit because they don’t have to worry about the randomness of play, the stuff you see in the commercials, right before the “rated T for teen” part. I don’t know if I just had a bad projector or what, but I spent the bulk of this long movie distracted by how dreadful everything looked. With a few small exceptions — The Shire glows with lovely green, a mountain cave fight/chase sequence is bracingly rich — this is a dismally unattractive movie, featuring too many shots that I’m sure were lovely at some point but are too often ruined and chintzified by the terrible technology monster.


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So on its aesthetic merits, The Hobbit comes up more than short. The trouble is, it’s not rescued by many narrative successes. Jackson has taken largely from the first third of J.R.R. Tolkien‘s novel — about an expedition to reclaim a lost dwarf kingdom from a dragon — but he’s also added in some elements found in appendices detailing an expanded universe that Tolkien included in an edition of The Lord of the Rings. This is partly to flesh out the story as Jackson believes Tolkien meant it to be, but it’s also meant to satisfy the needs of a supersize film trilogy based on one mere book. And so we get several pointless and uninteresting diversions, mostly about dwarves and their bitter enemies the orcs, that read exactly like the filler they are. Jackson is trying to flesh out dwarf mythology, because we spend so much of our time with these little guys, but it feels tediously synthetic, as if there are two movies competing for attention with neither one getting its due. We go to the goblin caves of The Hobbit and then, upon deliverance from that dark place, are thrust right into some kind of honor-and-revenge-based conflict with a snarling, giant, one-armed orc. It’s all very crowded and strangely hurried for a movie that, all told, takes its sweet time.


RELATED: No One Likes Peter Jackson’s New ‘Hobbit’ Footage


I suspect that another of Jackson’s reasons for including all this extra dramatic battling is that, on its own, The Hobbit is something of a children’s book. We’ve got wacky, food-crazed dwarves, a mean old dragon, and a funny little guy to take us along on the journey. Jackson doesn’t deny his movie the kiddie flourishes — there’s snot humor and butt jokes and lots of other goofy stuff involving some trolls, plus two little musical numbers involving all the dwarves — but he then tries to complement them with the big, booming faith and honor stuff and it never properly congeals. One moment we’re on a sprightly children’s adventure, the next we’re talking in big fashion about all that warlike serious business. It’s a discordant mix, and I’d imagine it will leave both kids and adults out in the cold.


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The film is not without its bright spots, rare as they may be. Ian McKellen is a feisty, spirited, mysterious Gandalf as ever before, and Martin Freeman nicely and genially projects everyday hobbit-ness, even if he’s a tad underused in the film. (Yeah, in the movie called The Hobbit, there’s barely any time to focus on the darn Hobbit.) Cate Blanchett turns up once more as the ethereal elf Galadriel, lending the movie a cool classiness and a welcome dose of feminine energy. And, of course, we’re back, for one mesmerizing scene, with our beloved Gollum, so winningly and creepily played by Andy Serkis, and here yet another marvel of computer innovation. In some ways Gollum’s innate cartoonishness works better now than it did in the original trilogy, which is probably the only time that can be said of this movie. There are one or two moments in Gollum’s pivotal scene where he’s given a bit too much modern humor to play, but all told he’s the most welcome sight in the film. Maybe that’s just the newfound purist in me, yearning for the old days, but I suspect it has more to do with Gollum being the only genuinely realized character we’ve so far encountered in this new trio of films. Everyone else is a snoozy lesser version of someone else, especially the ridiculous bloodthirsty orc leader, who snarls and growls like something out of the Underworld movies. Sometimes, in the jumble of the The Hobbit‘s many cluttered and dull action scenes, the frantic blur looks like any sequence from one of those schlocky ’00s B-movies; all roughly hewn CGI clashing around nonsensically, with this orc fellow leading the charge.


RELATED: ‘The Hobbit’ Might Be Three Movies Now?


Despite all the technical advancements, if we can call them that, most moments in The Hobbit feel like Peter Jackson is sadly trying to make all those familiar LOTR elements work for him once more, without ever really being able to reignite the old flame. The supposedly awe-inducing visit to the elf city of Rivendell is a ho-hum experience in this new frame-rate-ruined world. A silly battle sequence involving a wizard, a silly Radagast the Brown, riding around pell-mell on a rabbit-drawn sled looks like an interstitial from late-era Super Mario. Even Elijah Wood, appearing briefly as Frodo, looks strange — a pale ghost of himself, as if stitched in from another movie by some forlorn and desperate hand. The film is inevitably resonant with memories of the original trilogy, and little about it can hold up to the comparison. There’s too much effort in the wrong places — action instead of story, technical tricks instead of actual design — and the constant rhythm of arbitrary event after arbitrary event becomes tiresome well before the film’s two hours and forty minutes have lurched to a halt. I’m sure there are kids who will like this wan, distracted effort — they might not yet have anything else to compare it to, depending on their age — but as a human who remembers what came before, I’m afraid The Hobbit left me nothing but frustrated, sad, and tired. Frustrated that these big-budget visionaries seem to consistently feel they have to taint their earlier masterpieces with techno-junk followups, sad that once magical lands now flicker cheap and garish in my head, and tired at the prospect of two more of these things. I exited the theater trying to remind myself that Attack of the Clones was way better than Phantom Menace and that Revenge of the Sith was better still. I then realized how depressing it was that I was making that comparison. Oh, Middle Earth. What has become of you?


Gaming News Headlines – Yahoo! News


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Eric Clapton, Bruce Springsteen, Kanye West & More Perform for Sandy Relief















12/12/2012 at 06:30 PM EST







Kanye, Bon Jovi, Alicia Keys and Bruce Springsteen


Kevin Mazur/WireImage; Jamie McCarthy/Getty; WireImage; Tim Mosenfelder/Getty


It's time for a concert for a great cause.

On Wednesday at 7:30 p.m., musicians including Bruce Springsteen, Paul McCartney, Alicia Keys and Kanye West will take the stage at Madison Square Garden for the 12-12-12 Concert for Sandy Relief.

The concert will raise money to benefit those affected by the superstorm in New York, New Jersey and Connecticut.

The show will be broadcast for free at movie theaters in the tri-state area, offering those impacted by Sandy the opportunity to enjoy a night of music, but you can watch a live stream here on PEOPLE.com.

Other performers include Bon Jovi, Dave Grohl, Billy Joel, Coldplay's Chris Martin, Eddie Vedder, Roger Waters and The Who.

Join us tonight for this historic event.

For more information, visit www.121212concert.org, and check back on PEOPLE.com Thursday morning for highlights from star-studded concert!

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Congress examines science behind HGH test for NFL


WASHINGTON (AP) — A congressional committee has opened a hearing to examine the science behind a human growth hormone test the NFL wants to start using on its players.


Nearly two full seasons have passed since the league and the players' union signed a labor deal that set the stage for HGH testing.


The NFL Players Association won't concede the validity of a test that's used by Olympic sports and Major League Baseball, and the sides haven't been able to agree on a scientist to help resolve that impasse.


Among the witnesses before the House Oversight and Government Reform Committee on Wednesday is Pro Football Hall of Fame member Dick Butkus. In his prepared statement, Butkus writes: "Now, let's get on with it. The HGH testing process is proven to be reliable."


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Doctor caught with 1,000 child porn images, police say




Dr. Pete ThomasA
Santa Ana foot doctor was arrested Tuesday on a warrant accusing him of possessing more
than 1,000 images of child pornography on his company computer.


Dr. Pete Thomas, 58, of Coastline Podiatry in Santa Ana, surrendered to a judge
Tuesday and was booked into Santa Ana jail before being released on $50,000 bail,
Santa Ana police Cpl. Anthony Bertagna said.


The images were first discovered by a
computer technician who was servicing company computers, Bertagna said. The technician told his bosses, who alerted
police in late October.


Detectives then seized the computer, and upon being
granted a search warrant, sent it to an FBI forensics lab, authorties said. There, investigators
located more than 1,000 images of children between age 7 and “early teenage
years,” who were  “involved
in sex acts with other kids and adults,” Bertagna
said.


“Right now, there is no evidence that he’s had any
personal contact with the children in the photographs,” Bertagna added.


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Seeking Allies Among Syrian Rebels, U.S. Instead Finds Hostility


Narciso Contreras/Associated Press


Free Syrian Army fighters aimed their weapons during heavy clashes with government forces in Aleppo.







BEIRUT, Lebanon — As the United States tries attempts to rally international support for the Syrian rebellion, trying to herd the opposition into a shadow government that it can recognize and assist, on the ground in Syria it faces an entirely different problem: Much of the rebellion is hostile toward America.




Frustration mounted for months as the United States sat on the sidelines, and peaked this week when it blacklisted the Nusra Front, one of the uprising’s most effective fighting forces, calling it a terrorist organization. The move was aimed at isolating the group, which according to Iraqi and American officials has operational ties to Al Qaeda’s franchise in Iraq.


But interviews with a wide range of Syrian rebels and activists show that for now, the blacklisting has appeared to produce the opposite. It has united a broad spectrum of the opposition — from Islamist fighters to liberal and nonviolent activists who fervently oppose them — in anger and exasperation with the United States. The dissatisfaction is over more than just the blacklisting, and raises the possibility that now, just as the United States is stepping up efforts to steer the outcome in Syria, it may already be too late.


More than 100 antigovernment organizations and fighting battalions have called online for demonstrations on Friday under the slogan, “No to American intervention — we are all Jabhet al-Nusra,” a reference to the group’s Arabic name.


Syrians across the political spectrum say the United States allowed more than 40,000 people to die in the 21-month conflict. Supporters of the Syrian president, Bashar al-Assad, call the uprising a creation of the West and its allies. His opponents excoriate the United States for failing to provide arms and leaving them to perish — and have begun to express a growing wariness of American involvement in Syria’s political future.


“Anti-American sentiment is growing, because the Americans are messing up in bigger ways lately,” said Nabil al-Amir, an official spokesman for the rebel military council for Damascus and its suburbs, one of the committees that the United States and its allies are trying to coax into a unified rebel command. With every step to correct earlier mistakes, he said, “they make a bigger mess.”


Liberals activists blame American inaction for giving jihadists a leading role in the conflict. Rival rebel groups have declared solidarity with the Nusra Front, and Islamists have congratulated it on its new distinction. And seemingly everyone accuses the United States of hypocrisy for not putting a terrorist label on Mr. Assad, whose forces have killed far more civilians than any rebel group.


The United States scrambled on Tuesday to contain the damage, issuing a more complete justification for blacklisting the Nusra Front and stressing that the group has killed Syrian civilians in more than 40 suicide bombings. And it announced a new wrinkle: It is also blacklisting pro-government militias accused of killing civilians as part of “the Assad regime’s campaign of terror and violence.”


The militias, a Treasury Department statement said, would include what it called “the Shabiha” and Jaish al-Sha’bi, or the People’s Army, which it said was created with the help of Mr. Assad’s allies Iran and the Lebanese Shiite group Hezbollah and was modeled on Iran’s Basij militia.


But it may be hard to define who exactly is blacklisted under the heading of “shabiha,” which is not the name of an organization but a catchall term for pro-government gangs. The People’s Army is a nascent group, an apparent effort to turn those informal militias into a paramilitary organization.


Criticizing America has become a favorite sideline of antigovernment activists. Some have even questioned the sincerity of President Obama’s recent warning that Mr. Assad would be crossing “a red line” if he used chemical weapons on Syrians.


At a recent demonstration, solemn-eyed boys posed for a photograph that spread online with the title “Red line or green light?” They held a poster of a traffic light, emblazoned with an American flag, shining green for Mr. Assad as he drives a truck laden with chemical weapons.


Demonstrators in Kafr Nabl, a northern Syrian town known lately for its witty antigovernment slogans, quickly mocked the blacklisting with a poster that showed a cartoonish Mr. Assad, with jutting ears, a diabolical grimace and a bloody dagger in each hand, standing over a pile of corpses. One of the dead held a black banner with an Islamic slogan as Mr. Obama, his back to the massacre, pointed at the banner and said, “Terrorist!”


Michael R. Gordon contributed reporting from Washington.



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Hugh Hefner's Engagement Ring to Crystal Harris Revealed















12/11/2012 at 07:00 PM EST



The wedding's back on – though it may be a good idea to save that gift receipt.

Hugh Hefner, 86, officially confirms that he is once again engaged to Crystal Harris, 26, telling his Twitter followers, "I've given Crystal Harris a ring. I love the girl."

And to prove it, Harris posted photos of the big diamond sparkler, calling it "my beautiful ring."

Neither announced a wedding date, though sources tell PEOPLE they're planning to tie the knot at the Playboy Mansion in Los Angeles on New Year's Eve.

Whether that still happens remains to be seen.

This is the plan they had in 2011 – a wedding at the mansion – except that Harris called it off just days before the nuptials were scheduled to happen in front of 300 invited guests.

Hugh Hefner's Engagement Ring to Crystal Harris Revealed| Engagements, Crystal Harris, Hugh Hefner

Hugh Hefner and Crystal Harris

David Livingston / Getty

The onetime Playmate of the Month then ripped Hef's bedroom skills, calling him a two-second man, to which Hefner replied, "I missed a bullet" by not marrying her.

A year later, Hefner's "runaway bunny" bounded back to him.

Reporting by JENNIFER GARCIA

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DA investigating Texas' troubled $3B cancer agency


AUSTIN, Texas (AP) — Turmoil surrounding an unprecedented $3 billion cancer-fighting effort in Texas worsened Tuesday when its executive director offered his resignation and the state's chief public corruption prosecutor announced an investigation into the beleaguered agency.


No specific criminal allegations are driving the latest probe into the Cancer Prevention and Research Institute of Texas, said Gregg Cox, director of the Travis County district attorney's public integrity unit. But his influential office opened a case only weeks after the embattled agency disclosed that an $11 million grant to a private company bypassed review.


That award is the latest trouble in a tumultuous year for CPRIT, which controls the nation's second-largest pot of cancer research dollars. Amid the mounting problems, the agency announced Tuesday that Executive Director Bill Gimson had submitted his letter of resignation.


"Unfortunately, I have also been placed in a situation where I feel I can no longer be effective," Gimson wrote in a letter dated Monday.


Gimson said the troubles have resulted in "wasted efforts expended in low value activities" at the agency, instead of a focused fight against cancer. Gimson offered to stay on until January, and the agency's board must still approve his request to step down.


His departure would complete a remarkable house-cleaning at CPRIT in a span of just eight months. It began in May, when Dr. Alfred Gilman resigned as chief science officer in protest over a different grant that the Nobel laureate wanted approved by a panel of scientists. He warned it would be "the bomb that destroys CPRIT."


Gilman was followed by Chief Commercialization Officer Jerry Cobbs, whose resignation in November came after an internal audit showed Cobbs included an $11 million proposal in a funding slate without a required outside review of the project's merits. The lucrative grant was given to Dallas-based Peloton Therapeutics, a biomedical startup.


Gimson chalked up Peloton's award to an honest mistake and has said that, to his knowledge, no one associated with CPRIT stood to benefit financially from the company receiving the taxpayer funds. That hasn't satisfied some members of the agency's governing board, who called last week for more assurances that no one personally profited.


Cox said he has been following the agency's problems and his office received a number of concerned phone calls. His department in Austin is charged with prosecuting crimes related to government officials; his most famous cases include winning a conviction against former U.S. House Majority Leader Tom DeLay in 2010 on money laundering charges.


"We have to gather the facts and figure what, if any, crime occurred so that (the investigation) can be focused more," Cox said.


Gimson's resignation letter was dated the same day the Texas attorney general's office also announced its investigation of the agency. Cox said his department would work cooperatively with state investigators, but he made clear the probes would be separate.


Peloton's award marks the second time this year that a lucrative taxpayer-funded grant authorized by CPRIT instigated backlash and raised questions about oversight. The first involved the $20 million grant to M.D. Anderson Cancer Center in Houston that Gilman described as a thin proposal that should have first been scrutinized by an outside panel of scientific peer-reviewers, even though none was required under the agency's rules.


Dozens of the nation's top scientists agreed. They resigned en masse from the agency's peer-review panels along with Gilman. Some accused the agency of "hucksterism" and charting a politically-driven path that was putting commercial product-development above science.


The latest shake-up at CPRIT caught Gilman's successor off-guard. Dr. Margaret Kripke, who was introduced to reporters Tuesday, acknowledged that she wasn't even sure who she would be answering to now that Gimson was stepping down. She said that although she wasn't with the agency when her predecessor announced his resignation, she was aware of the concerns and allegations.


"I don't think people would resign frivolously, so there must be some substance to those concerns," Kripke said.


Kripke also acknowledged the challenge of restocking the peer-review panels after the agency's credibility was so publicly smeared by some of the country's top scientists. She said she took the job because she felt the agency's mission and potential was too important to lose.


Only the National Institutes of Health doles out more cancer research dollars than CPRIT, which has awarded more than $700 million so far.


Gov. Rick Perry told reporters in Houston on Tuesday that he wasn't previously aware of the resignation but said Gimson's decision to step down was his own.


Joining the mounting criticism of CPRIT is the woman credited with brainstorming the idea for the agency in the first place. Cathy Bonner, who served under former Texas Gov. Ann Richards, teamed with cancer survivor Lance Armstrong in selling Texas voters in 2007 on a constitutional amendment to create an unprecedented state-run effort to finance a war on disease.


Now Bonner says politics have sullied an agency that she said was built to fund research, not subsidize private companies.


"There appears to be a cover-up going on," Bonner said.


Peloton has declined comment about its award and has referred questions to CPRIT. The agency has said the company wasn't aware that its application was never scrutinized by an outside panel, as required under agency rules.


___


Follow Paul J. Weber on Twitter: www.twitter.com/pauljweber


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