Huge study: 5 mental disorders share genetic links


WASHINGTON (AP) — The largest genetic study of mental illnesses to date finds five major disorders may not look much alike but they share some gene-based risks. The surprising discovery comes in the quest to unravel what causes psychiatric disorders and how to better diagnose and treat them.


The disorders — autism, attention deficit-hyperactivity disorder or ADHD, bipolar disorder, major depressive disorder and schizophrenia — are considered distinct problems. But findings published online Wednesday suggest they're related in some way.


"These disorders that we thought of as quite different may not have such sharp boundaries," said Dr. Jordan Smoller of Massachusetts General Hospital, one of the lead researchers for the international study appearing in The Lancet.


That has implications for learning how to diagnose mental illnesses with the same precision that physical illnesses are diagnosed, said Dr. Bruce Cuthbert of the National Institute on Mental Health, which funded the research.


Consider: Just because someone has chest pain doesn't mean it's a heart attack; doctors have a variety of tests to find out. But there's no blood test for schizophrenia or other mental illnesses. Instead, doctors rely on symptoms agreed upon by experts. Learning the genetic underpinnings of mental illnesses is part of one day knowing if someone's symptoms really are schizophrenia and not something a bit different.


"If we really want to diagnose and treat people effectively, we have to get to these more fine-grained understandings of what's actually going wrong biologically," Cuthbert explained.


Added Mass General's Smoller: "We are still in the early stages of understanding what are the causes of mental illnesses, so these are clues."


The Psychiatric Genomics Consortium, a collaboration of researchers in 19 countries, analyzed the genomes of more than 61,000 people, some with one of the five disorders and some without. They found four regions of the genetic code where variation was linked to all five disorders.


Of particular interest are disruptions in two specific genes that regulate the flow of calcium in brain cells, key to how neurons signal each other. That suggests that this change in a basic brain function could be one early pathway that leaves someone vulnerable to developing these disorders, depending on what else goes wrong.


For patients and their families, the research offers no immediate benefit. These disorders are thought to be caused by a complex mix of numerous genes and other risk factors that range from exposures in the womb to the experiences of daily life.


"There may be many paths to each of these illnesses," Smoller cautioned.


But the study offers a lead in the hunt for psychiatric treatments, said NIMH's Cuthbert. Drugs that affect calcium channels in other parts of the body are used for such conditions as high blood pressure, and scientists could explore whether they'd be useful for psychiatric disorders as well.


The findings make sense, as there is some overlap in the symptoms of the different disorders, he said. People with schizophrenia can have some of the same social withdrawal that's so characteristic of autism, for example. Nor is it uncommon for people to be affected by more than one psychiatric disorder.


___


Online:


http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)60223-8/abstract


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Imperial County betting its future on renewable energy









Situated in the southeastern corner of California, bordering Arizona and Mexico, Imperial County has long depended on agriculture and cash crops that grew from the good earth.


But lately the region — which carries the dubious distinction of having the state's highest unemployment rate at 25.5% — is betting its future on a different kind of farm: green energy.


Spurred by a state mandate that requires utilities to get a third of their electricity from green sources by 2020, renewable energy companies are leasing or buying thousands of acres in Imperial County to convert to energy farms providing power for coastal cities — bringing an estimated 6,000 building jobs and billions in construction activity to the county.





Although renewable energy projects are sprouting up across the Golden State, no county needs them as much as Imperial, which has consistently ranked as the worst-performing region of California even in boom times.


The prospect of a construction boom has excited residents hungry for work. But some farmers and Native American tribes are crying foul, angry that the new projects are encroaching on land that they claim has cultural value or should be devoted to crops.


Solar, wind and geothermal projects are popping up on farms that once grew wheat, alfalfa and sugar beets. County officials say the normally hardscrabble region is benefiting from vast tracts of affordable land and lots of sunshine, the one resource the region can almost always count on.


"It's sunny 365 days of the year, damn near," boasted Mike Kelley, chairman of the county's Board of Supervisors. "Renewable energy is going to give Imperial County a shot in the arm."


Local advocates are betting that a "green rush" will lift a county that has struggled with economic upheaval. The Bureau of Labor Statistics just ranked El Centro as the second-worst metro area for job hunters, after Yuma, Ariz. Its unemployment rate fluctuated between 25% and 33% from 2010 and 2012.


Two of the county's top five employers are the Calipatria and Centinela state prisons. The agriculture sector shed jobs as farmers moved to automation and switched to less labor-intensive crops. Construction work vanished when El Centro, the county's biggest city, was hit hard by the housing crisis. Long-standing businesses such as a food processing plant moved elsewhere, taking away hundreds of jobs.


But with green energy companies scrambling to build solar installations and wind farms throughout the county, some residents are convinced that Imperial's fortunes will soon be looking up.


Tenaska Solar Ventures plans to break ground this year on its second project in the county after nearing completion on its first site, known as the Imperial Solar Energy Center South, on nearly 1,000 acres near El Centro.


The company came to the region both for its "abundant sunshine" and also proximity to the Sunrise Powerlink, a power transmission line completed last year that connects Imperial and San Diego counties, said Bob Ramaekers, Tenaska's vice president of development.


More than 500 construction workers have been hired to work on Tenaska Imperial South, with 70% coming from the local community, he said. A job fair held last year drew about 1,200 applicants. The second project will generate as many as 300 construction jobs, with priority given to local hires.


"One of the advantages of solar projects is they are not really high-tech. Anyone who has worked at all in the construction business can work in a solar facility," said Andy Horne, deputy executive officer of the county's natural resources department. "It's like a big erector set — you bolt these things together and ba-da-bing, you have a solar project."


The lure of a steady, well-paid job is what persuaded Victor Santana, 27, to start training as a journeyman electrician two years ago. He had studied film in college and hoped to make movies, but ended up working a series of odd jobs after the economic downturn — driving tractors, operating hay presses, selling vacuum cleaners. Even a video-editing gig he eventually found paid minimum wage,


"Things had dried up. There was only field work, or fast food, or working at the local mall," the El Centro resident said.


Santana finally decided to switch careers after hearing the pitch from green energy companies trickling into town. Now he earns about $21 an hour with regular raises every six months, and the prospect of steady work for another seven to 10 years just from the stream of solar and wind projects. "I feel a lot more secure than I did," he said.


Green energy may help Imperial hold onto its young people, who often try to land a government job or leave the county altogether in search of better-paying jobs elsewhere. Calipatria Unified School District is launching a vocational program this fall to prepare high school graduates for jobs in renewable energy. San Diego State is building a power plant simulator at its Brawley campus.


"With the advent of renewable energy, we are seeing a different kind of industrial base," said Mike Sabath, associate dean of academic affairs at San Diego State's Imperial Valley campus. "Hopefully that will provide opportunities to develop more job stability in the region than what we have enjoyed."


But construction has raised the hackles of some locals. There are farmers wringing their hands over fertile land snapped up by energy companies; they worry that a way of life is being edged out by corporations eager to cash in on the modern gold rush.





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Rocket From Gaza Hits Israel, Breaking Cease-Fire


Tsafrir Abayov/Associated Press


Israeli explosives experts gathered near a rocket believed to have been fired from the Gaza Strip, landing near Ashkelon, on Tuesday.







JERUSALEM — A Grad rocket fired from the Gaza Strip struck in southern Israel early Tuesday, threatening to further escalate tensions that have been mounting since Saturday, when a 30-year-old Palestinian prisoner died in an Israeli jail.




The rocket, which came down on a road outside the city of Ashkelon and caused no injuries, was the first from Gaza to hit Israel in the three months since a cease-fire agreement ended eight days of cross-border violence. Israel has violated the cease-fire several times by firing on fishermen and farmers approaching newly relaxed security perimeters, but the agreement has otherwise held.


A subgroup of the Al Aksa Martyrs Brigade, the military wing of the Palestinians’ Fatah faction, said it fired the rocket in response to what it called the “assassination” of Arafat Jaradat, the prisoner who died on Saturday. Palestinian leaders have blamed Mr. Jaradat’s death on what they described as “severe torture” during interrogation, though Israeli officials say the bruising and broken ribs cited as evidence of torture could have been caused by resuscitation efforts.


Mushir al-Masri, a lawmaker from the militant Hamas faction that rules the Gaza Strip, said in an interview that Israel was “fully responsible for the consequences of the wave of the Palestinian public fury.”


After the rocket attack, Israel shut its border crossings with Gaza to goods and people, allowing only “medical, humanitarian and exceptional cases,” according to a statement from the military. President Shimon Peres, who was visiting southern Israel on a previously scheduled tour, said, “Quiet will be met with quiet; missiles will be met with a response.”


Giora Eiland, a senior research fellow at Israel’s Institute for National Security Studies, said renewed rocket fire could change the current delicate balance between Israel and the Palestinians, because international opinion is largely critical of Israel’s actions in the West Bank but is sympathetic when Israel comes under attack from Gaza.


“I believe that it is under control, it can be contained, and with some gestures from both sides and clear messages from Washington — which I understand are coming every few hours — it will be able to prevent an escalation and not to deteriorate ourselves to a third intifada,” Mr. Eiland said, using the Arabic word for uprising. “There is a very delicate line between two conflicting interests: to do something in order to preserve the Jihadiic identity, to preserve the spirit of resistance, to serve so many domestic interests, but not to do something that would bring some unproportional response.”


Fares Akram contributed reporting from Gaza City.



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See Which Star Dyed Her Hair Red for The Amazing Spider-Man







Style News Now





02/26/2013 at 12:30 PM ET











Shailene Woodley Red Hair
Splash News Online; Inset: Landov


Emma Stone went blonde for her role in the Spider-Man series, and now another star has made a change for the franchise. Shailene Woodley debuted new red locks on Monday, while snapped on the New York City set of the second film in the series, The Amazing Spider-Man 2.


Woodley, who has several films in production for the year ahead, generally has highlighted brunette hair, so the new hue is a big change — one we’re liking!


The Descendants starlet plays redheaded Peter Parker love interest Mary Jane Watson in the upcoming film, set for release in 2014. (In the last Spider Man series, Kirsten Dunst filled Mary Jane’s shoes — and also went red for the role.)


Stone and boyfriend Andrew Garfield, who plays Parker, are both returning for the movie, as are Sally Field and Martin Sheen. Jamie Foxx, Paul Giamatti and Felicity Jones are joining the cast, as well. Tell us: What do you think of Woodley’s new do?




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C. Everett Koop, 'rock star' surgeon general, dies


NEW YORK (AP) — Dr. C. Everett Koop has long been regarded as the nation's doctor— even though it has been nearly a quarter-century since he was surgeon general.


Koop, who died Monday at his home in Hanover, N.H., at age 96, was by far the best known and most influential person to carry that title. Koop, a 6-foot-1 evangelical Presbyterian with a biblical prophet's beard, donned a public health uniform in the early 1980s and became an enduring, science-based national spokesman on health issues.


He served for eight years during the Reagan administration and was a breed apart from his political bosses. He thundered about the evils of tobacco companies during a multiyear campaign to drive down smoking rates, and he became the government's spokesman on AIDS when it was still considered a "gay disease" by much of the public.


"He really changed the national conversation, and he showed real courage in pursuing the duties of his job," said Chris Collins, a vice president of amfAR, the Foundation for AIDS Research.


Even before that, he had been a leading figure in medicine. He was one of the first U.S. doctors to specialize in pediatric surgery at a time when children with complicated conditions were often simply written off as untreatable. In the 1950s, he drew national headlines for innovative surgeries such as separating conjoined twins.


His medical heroics are well noted, but he may be better remembered for transforming from a pariah in the eyes of the public health community into a remarkable servant who elevated the influence of the surgeon general — if only temporarily.


"He set the bar high for all who followed in his footsteps," said Dr. Richard Carmona, who served as surgeon general a decade later under President George W. Bush.


Koop's religious beliefs grew after the 1968 death of his son David in a mountain-climbing accident, and he became an outspoken opponent of abortion. His activism is what brought him to the attention of the administration of President Ronald Reagan, who decided to nominate him for surgeon general in 1981. Though once a position with real power, surgeon generals had been stripped of most of their responsibilities in the 1960s.


By the time Koop got the job, the position was kind of a glorified health educator.


But Koop ran with it. One of his early steps involved the admiral's uniform that is bestowed to the surgeon general but that Koop's predecessors had worn only on ceremonial occasions. In his first year in the post, Koop stopped wearing his trademark bowties and suit jackets and instead began wearing the uniform, seeing it as a way to raise the visual prestige of the office.


In those military suits, he surprised the officials who had appointed him by setting aside his religious beliefs and feelings about abortion and instead waging a series of science-based public health crusades.


He was arguably most effective on smoking. He issued a series of reports that detailed the dangers of tobacco smoke, and in speeches began calling for a smoke-free society by the year 2000. He didn't get his wish, but smoking rates did drop from 38 percent to 27 percent while he was in office — a huge decline.


Koop led other groundbreaking initiatives, but perhaps none is better remembered than his work on AIDS.


The disease was first identified in 1981, before Koop was officially in office, and it changed U.S. society. It destroyed the body's immune system and led to ghastly death, but initially was identified in gay men, and many people thought of it as something most heterosexuals didn't have to worry about.


U.S. scientists worked hard to identify the virus and work on ways to fight it, but the government's health education and policy efforts moved far more slowly. Reagan for years was silent on the issue. Following mounting criticism, Reagan in 1986 asked Koop to prepare a report on AIDS for the American public.


His report, released later that year, stressed that AIDS was a threat to all Americans and called for wider use of condoms and more comprehensive sex education, as early as the third grade. He went on to speak frankly about AIDS in an HBO special and engineered the mailing of an educational pamphlet on AIDS to more than 100 million U.S. households in 1988.


Koop personally opposed homosexuality and believed sex should be saved for marriage. But he insisted that Americans, especially young people, must not die because they were deprived of explicit information about how HIV was transmitted.


Koop's speeches and empathetic approach made him a hero to a wide swath of America, including public health workers, gay activists and journalists. Some called him a "scientific Bruce Springsteen." AIDS activists chanted "Koop, Koop" at his appearances and booed other officials.


"I was walking down the street with him one time" about five years ago, recalled Dr. George Wohlreich, director of the College of Physicians of Philadelphia, a medical society with which Koop had longstanding ties. "People were yelling out, 'There goes Dr. Koop!' You'd have thought he was a rock star."


Koop angered conservatives by refusing to issue a report requested by the Reagan White House, saying he could not find enough scientific evidence to determine whether abortion has harmful psychological effects on women.


He got static from some staff at the White House for his actions, but Reagan himself never tried to silence Koop. At a congressional hearing in 2007, Koop spoke about political pressure on the surgeon general post. He said Reagan was pressed to fire him every day.


After his death was reported Monday, the tributes poured forth, including a statement from New York Mayor Michael Bloomberg, who has made smoking restrictions a hallmark of his tenure.


"The nation has lost a visionary public health leader today with the passing of former Surgeon General C. Everett Koop, who was born and raised in Brooklyn," Bloomberg said. "Outspoken on the dangers of smoking, his leadership led to stronger warning labels on cigarettes and increased awareness about second-hand smoke, creating an environment that helped millions of Americans to stop smoking — and setting the stage for the dramatic changes in smoking laws that have occurred over the past decade."


Dr. Anthony Fauci of the National Institutes of Health taught Koop what was known about AIDS during quiet after-hours talks in the early 1980s and became a close friend.


"A less strong person would have bent under the pressure," Fauci said. "He was driven by what's the right thing to do."


Carmona, a surgeon general years later, said Koop was a mentor who preached the importance of staying true to the science in speeches and reports — even when it made certain politicians uncomfortable.


"We remember him for the example he set for all of us," Carmona said.


Koop's nomination originally was met with staunch opposition. Women's groups and liberal politicians complained Reagan had selected him only because of his conservative views, especially his staunch opposition to abortion.


Foes noted that Koop traveled the country in 1979 and 1980 giving speeches that predicted a progression "from liberalized abortion to infanticide to passive euthanasia to active euthanasia, indeed to the very beginnings of the political climate that led to Auschwitz, Dachau and Belsen."


But Koop, a devout Presbyterian, was confirmed as surgeon general after he told a Senate panel he would not use the post to promote his religious ideology. He kept his word and eventually won wide respect with his blend of old-fashioned values, pragmatism and empathy.


Koop was modest about his accomplishments, saying before leaving office in 1989, "My only influence was through moral suasion."


The office declined after that. Few of his successors had his speaking ability or stage presence. Fewer still were able to secure the support of key political bosses and overcome the meddling of everyone else. The office gradually lost prestige and visibility, and now has come to a point where most people can't name the current surgeon general. (It's Dr. Regina Benjamin.)


Even after leaving office, Koop continued to promote public health causes, from preventing childhood accidents to better training for doctors.


"I will use the written word, the spoken word and whatever I can in the electronic media to deliver health messages to this country as long as people will listen," he promised.


In 1996, he rapped Republican presidential hopeful Bob Dole for suggesting that tobacco was not invariably addictive, saying Dole's comments "either exposed his abysmal lack of knowledge of nicotine addiction or his blind support of the tobacco industry."


He maintained his personal opposition to abortion. After he left office, he told medical students it violated their Hippocratic oath. In 2009, he wrote to Senate Majority Leader Harry Reid, urging that health care legislation include a provision to ensure doctors and medical students would not be forced to perform abortions. The letter briefly set off a security scare because it was hand delivered.


Koop served as chairman of the National Safe Kids Campaign and as an adviser to President Bill Clinton's health care reform plan.


Worried that medicine had lost old-fashioned caring and personal relationships between doctors and patients, Koop opened an institute at Dartmouth College in New Hampshire to teach medical students basic values and ethics. He also was a part-owner of a short-lived venture, drkoop.com, to provide consumer health care information via the Internet.


Koop was the only son of a Manhattan banker and the nephew of a doctor. He said by age 5 he knew he wanted to be a surgeon and at age 13 he practiced his skills on neighborhood cats. He attended Dartmouth, where he received the nickname Chick, short for "chicken Koop." It stuck for life.


He received his medical degree at Cornell Medical College, choosing pediatric surgery because so few surgeons practiced it. In 1938, he married Elizabeth Flanagan, the daughter of a Connecticut doctor. They had four children. Koop's wife died in 2007, and he married Cora Hogue in 2010.


He was appointed surgeon-in-chief at Children's Hospital in Philadelphia and served as a professor at the University of Pennsylvania School of Medicine. He pioneered surgery on newborns and successfully separated three sets of conjoined twins. He won national acclaim by reconstructing the chest of a baby born with the heart outside the body.


Although raised as a Baptist, he was drawn to a Presbyterian church near the hospital, where he developed an abiding faith. He began praying at the bedside of his young patients — ignoring the snickers of some of his colleagues.


___


Contributing to this report were Associated Press writers Wilson Ring in Montpelier, Vt.; Jeff McMillan in Philadelphia; and AP Medical Writer Lauran Neergaard in Washington.


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Does Eric Garcetti keep his word? Accounts vary









Santiago Perez and his neighbors went straight to Councilman Eric Garcetti when they heard that a developer planned to build a 62-unit housing and retail development on their quiet street in Echo Park.


Worried that the four-story complex would tower over homes and bring excess traffic, the group emerged from their meeting at Los Angeles City Hall feeling relieved. "He told us that, yes, he's with us and he will do everything possible to reject the plan," Perez said.


But months later in front of the citywide Planning Commission, a Garcetti representative offered the lawmaker's tacit support for the project, saying it was "designed well" and would bring needed jobs and housing to the area.





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Perez and his neighbors felt blindsided. "He said one thing and then he did another," Perez said. One of his neighbors fired off an angry message via Twitter: "Eric Garcetti went back on his word."


If Garcetti succeeds in his bid to become L.A.'s next mayor, he will face new pressure to take decisive action on hotly contested issues. A number of colleagues and constituents say he has not always been a steadfast ally and decision maker.


Another mayoral front runner, Wendy Greuel, alluded to that allegation in a recent appearance before city workers, saying they need someone who will "be true to their word."


FULL COVERAGE: L.A.'s race for mayor


Garcetti insists he never wavers from a promise. In nearly 12 years in office, he has made decisions that have upset some people, he acknowledged. But the vast majority of people he has worked with have had positive experiences, he said.


He said that he never committed to fighting the Echo Park development and that he "reserves the right" to take his time forming a position on an issue. "I listen to a lot of people to make sure I'm as well-informed as possible up until the last hour," he said.


Councilman Bernard C. Parks, who has served alongside Garcetti for more than a decade, said Garcetti too often tests the political winds before taking a stand. Parks, who is backing Councilwoman Jan Perry's bid for mayor, alleges that Garcetti misled him last year by voting for a controversial redistricting plan after indicating he opposed it. Garcetti also undermined the city's efforts to hold down costs of employee union contracts, Parks said.


INTERACTIVE MAP: How Los Angeles voted


"I think he doesn't want to make an enemy of anyone," Parks said.


Garcetti said that he never told Parks he would oppose the redistricting plan and that the tough stance he took with the unions is "the reason I don't have [them] lining up behind me."


Questions of Garcetti's reliability arose for Marc Galucci, who went to the councilman for support in turning his Echo Park cafe into a restaurant serving beer and wine.


Galucci assembled neighbors to back his application for a liquor license for Fix Coffee, but parents of some children at a nearby school opposed it.


Galucci said Garcetti told him that he would remain neutral but offered suggestions on how to gain community support. Then, at 10 p.m. the night before the liquor license hearing, a Garcetti representative phoned. "Tomorrow at the hearing we're going to oppose this," she said.


"I was just flabbergasted," said Galucci. He later learned that Monica Garcia, president of the Board of the Los Angeles Unified School District, had asked Garcetti to oppose the request.


In the end, Galucci got the license, but he said the situation left him with a bad taste.


Garcetti acknowledged that the issue had been "a contentious one," but he said he had not pledged to remain neutral. He said that he initially liked the idea of a liquor permit for Fix but that community opposition "continued to grow and grow."





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Skepticism Surrounds Resumption of Nuclear Talks With Iran





ALMATY, Kazakhstan — Talks between Iran and six world powers over its nuclear program resume here on Tuesday after a break of eight months, but there is a general atmosphere of gloom about their prospects for success, even if narrowly defined.




Since talks in Moscow last June, Iran has continued to increase its stockpile of uranium enriched to 20 percent purity, has begun to install a new generation of centrifuges and has not yet completed an agreement on inspection of suspect military sites with the International Atomic Energy Agency, a deal originally advertised as all but done last May.


With presidential elections in Iran scheduled for June, senior Western diplomats involved with these talks expressed skepticism that Tehran’s chief negotiator, Saeed Jalili, would be willing to make compromises that could be portrayed as weakness at home.


Mr. Jalili is the personal representative of Iran’s supreme leader, Ayatollah Ali Khamenei, considered the dominant voice on the nuclear issue. Ayatollah Khamenei has recently expressed continued mistrust of the United States and its intentions, saying that he would not allow the kind of bilateral talks between Washington and Tehran that most analysts think would be crucial to any resolution.


At the same time, Iran has taken some of its stockpile of 20 percent enriched uranium and converted it into reactor fuel, which cannot easily be turned back. The conversion means that Iran now has less of the uranium needed to make a bomb, reducing the sense of urgency among the six powers, and Israel, that its nuclear program needs to be slowed.


But the total Iranian stockpile of 20 percent enriched uranium has nonetheless grown since November to 167 kilograms from 135 kilograms, according to the most recent I.A.E.A. report — closer to, if still significantly below, the 240 kilograms or 250 kilograms many experts consider necessary, once enriched further, to produce a nuclear weapon.


Iran denies that its nuclear program has any military aim. The six world powers, the so-called P5-plus-1 group, which are the five permanent members of the United Nations Security Council — Britain, China, France, Russia and the United States — and Germany, want Iran to obey Security Council resolutions ordering it to suspend enrichment and open itself up fully to I.A.E.A. inspectors, to ensure that there is no effort to build a nuclear weapon.


To press Iran to comply, the Security Council, the United States and the European Union have created an increasingly painful set of economic sanctions on Iran, as part of a dual-track strategy — negotiations and sanctions. Iran has for its part insisted that as a precondition for serious negotiations, the world should lift all the sanctions and recognize Iran’s “right to enrich,” which Iran asserts it has as a signatory to the Nuclear Nonproliferation Treaty.


The negotiations have been tedious, with Iran appearing to be playing for time, diplomats say. The six powers had asked for a resumption of these talks as early as December, but Iran rejected dates and sites before finally suggesting and agreeing upon Almaty. The choice pleased Western diplomats for its symbolic value, since Kazakhstan, when it became independent of the Soviet Union, freely relinquished the nuclear weapons it had inherited from Moscow. American officials are holding up Kazakhstan, one of the world’s largest producers of uranium and a maker of nuclear fuel, as an example to Iran of the benefits of peaceful nuclear energy and compliance with the I.A.E.A.


President Nursultan Nazarbayev of Kazakhstan appealed to Tehran in a New York Times Op-Ed article in March 2012 to abandon what he suggested was its pursuit of nuclear power status. “Kazakhstan’s experience shows that nations can reap huge benefits from turning their backs on nuclear weapons,” he wrote.


While expectations are low, the six hope to leave here with some momentum and signs of Iranian willingness to engage in what all have agreed should be a reciprocal and step-by-step process of lifting sanctions in return for Iranian actions to comply.


“Iran needs to understand that there is an urgent need to make concrete and tangible progress” in these talks, said Michael Mann, the spokesman for Catherine Ashton, the European Union’s foreign policy chief and chairwoman of the P5-plus-1 group.


Mr. Mann said that the six powers have together “prepared a good and updated offer for the talks which we believe is balanced and a fair basis for constructive talks” and that is “also responsive to Iranian ideas.”


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Oscar Gowns: The 12 Best Dresses of the Night









02/25/2013 at 05:50 PM EST








Jason Merritt/Getty; John Shearer/AP; Jeff Kravitz/FilmMagic


In order to earn a spot in the PEOPLE.com Oscars Best Dressed gallery, a gown must do one of two things: get the unanimous approval of the entire PEOPLE.com style staff…or wow one editor so much that she's prompted to start a campaign to get that star's look on the list (cough, Kerry Washington, cough).

Most of the names you see below fall under the former category, but there might be one or two fashion-forward looks that landed on the list because an editor was able to convince the team. Take a look and see if you can guess which those are.

1. JENNIFER LAWRENCE
We don't want to brag … okay, yes we do. We totally called this Dior Haute Couture number for the Best Actress nominee. She outdoes our expectations, though, pairing it with a Roger Vivier clutch and zillions of carats of Chopard jewels, including a dazzling necklace worn down her back.
• See the photo here.

2. JESSICA CHASTAIN
"It was a very tough decision," the Oscar nominee says of her copper embellished custom Giorgio Armani gown, accessorized with Harry Winston diamonds, soft waves and the perfect red lip. Maybe so, but it was certainly the right decision.
• See the photo here.

3. REESE WITHERSPOON
We might have selected Jennifer's dress, but it was Reese's daughter who helped pick out this two-tone Louis Vuitton creation, worn with gorgeous cascading waves. "She's 13, she really weighs in," the actress revealed of her young stylist.
• See the photo here.

4. AMY ADAMS
The nominee shows off her tiny waist (and penchant for dramatic dresses) in a silver-gray Oscar de la Renta gown with a beaded bodice and a massive, tulle-embellished skirt. She finishes the look with delicate jewelry and what just may be the night's prettiest undo.
• See the photo here.

5. CHARLIZE THERON
Who needs a statue when you look this statuesque? Charlize makes the most dramatic entrance of the evening thanks to her edgy crop, Harry Winston jewels and this pristine white peplum Dior Haute Couture, which prompted her to say, "I sometimes just really feel like a princess."
• See the photo here.

6. NAOMI WATTS
It'll be tough to out-dazzle the Impossible actress, whose fully sequined gunmetal Armani Privé gown features an asymmetric neckline and easily won over the PEOPLE.com editors. (Oh, and for those of you keeping count: She's also wearing $1.5 million of Neil Lane diamonds.)
• See the photo here.

7. KERRY WASHINGTON
"It's a coral-y, red, hot pink thing. I can't put a name on the color, which I love," the Django Unchained star explains of the reason she picked her simple Miu Miu gown with its bejeweled bodice. She also knocks it out of the park with her accessories: a Prada clutch, Chopard earrings, a Fred Leighton ring and Christian Louboutin heels.
• See the photo here.

8. STACY KEIBLER
Also predicting Oscar gowns accurately? Designer Naeem Khan, who guessed that we'd see this elegant beaded confection (paired with earrings and a bracelet by Lorraine Schwartz) on the red carpet tonight. Though we think he may have had a little insider info we didn't.
• See the photo here.

9. NICOLE KIDMAN
Major props to the Aussie actress for taking this fashion risk – it definitely paid off! She stuns in a L'Wren Scott gown that looks practically liquid, hugging her curves and ending in golden swirls, then tops it all off with Fred Leighton jewelry.
• See the photo here.

10. SANDRA BULLOCK
Though she's there to present, the star looks ready for center stage in her cap-sleeve Elie Saab gown with a sheer skirt, worn with Harry Winston jewels from her hair to her fingers, plus a vintage Daniel Swarovski clutch and Jimmy Choo heels.
• See the photo here.

11. JENNIFER GARNER
Affleck's arm candy fills the role beautifully yet again in a rich plum strapless Gucci gown with a dramatic back ruffle, plus $2.5 million worth of Neil Lane jewels including a 200 carat necklace, plus a Roger Vivier clutch.
• See the photo here.

12. KRISTEN STEWART
Despite having one of the night's most surprising accessories (a crutch), the actress looks poised and pretty in what could be a wedding gown – check out that cream lace and the tulle skirt on her Reem Acra creation – plus vintage Fred Leighton diamonds and Jimmy Choo heels.
• See the photo here.

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Koop, who transformed surgeon general post, dies


With his long silver beard and uniform with braided trim, former Surgeon General C. Everett Koop became one of the most recognizable figures of the Reagan era — and one of the most unexpectedly enduring.


His nomination in 1981 met a wall of opposition from women's groups and liberal politicians, who complained President Ronald Reagan selected Koop, a pediatric surgeon and evangelical Christian from Philadelphia, only because of his conservative views, especially his staunch opposition to abortion.


Soon, though, he was a hero to AIDS activists, who chanted "Koop, Koop" at his appearances but booed other officials. And when he left his post in 1989, he left behind a landscape where AIDS was a top research and educational priority, smoking was considered a public health hazard, and access to abortion remained largely intact.


Koop, who turned his once-obscure post into a bully pulpit for seven years during the Reagan and George H.W. Bush administrations and who surprised both ends of the political spectrum by setting aside his conservative personal views on issues such as homosexuality and abortion to keep his focus sharply medical, died Monday at his home in Hanover, N.H. He was 96.


An assistant at Koop's Dartmouth College institute, Susan Wills, confirmed his death but didn't disclose its cause.


Although the surgeon general has no real authority to set government policy, Koop described himself as "the health conscience of the country" and said modestly just before leaving his post that "my only influence was through moral suasion."


A former pipe smoker, Koop carried out a crusade to end smoking in the United States; his goal had been to do so by 2000. He said cigarettes were as addictive as heroin and cocaine. And he shocked his conservative supporters when he endorsed condoms and sex education to stop the spread of AIDS.


"A lot of people don't realize what an important role he played in the beginning of the AIDS epidemic. At the time, he really changed the national conversation, and he showed real courage in pursuing the duties of his job," said Chris Collins, a vice president of amFAR, the Foundation for AIDS Research.


Even after leaving office, Koop continued to promote public health causes, from preventing childhood accidents to better training for doctors.


"I will use the written word, the spoken word and whatever I can in the electronic media to deliver health messages to this country as long as people will listen," he promised.


In 1996, he rapped Republican presidential hopeful Bob Dole for suggesting that tobacco was not invariably addictive, saying Dole's comments "either exposed his abysmal lack of knowledge of nicotine addiction or his blind support of the tobacco industry."


Although Koop eventually won wide respect with his blend of old-fashioned values, pragmatism and empathy, his nomination met staunch opposition.


Foes noted that Koop traveled the country in 1979 and 1980 giving speeches that predicted a progression "from liberalized abortion to infanticide to passive euthanasia to active euthanasia, indeed to the very beginnings of the political climate that led to Auschwitz, Dachau and Belsen."


But Koop, a devout Presbyterian, was confirmed after he told a Senate panel he would not use the surgeon general's post to promote his religious ideology. He kept his word.


In 1986, he issued a frank report on AIDS, urging the use of condoms for "safe sex" and advocating sex education as early as third grade.


He also maneuvered around uncooperative Reagan administration officials in 1988 to send an educational AIDS pamphlet to more than 100 million U.S. households, the largest public health mailing ever.


Koop personally opposed homosexuality and believed sex should be saved for marriage. But he insisted that Americans, especially young people, must not die because they were deprived of explicit information about how HIV was transmitted.


Koop further angered conservatives by refusing to issue a report requested by the Reagan White House, saying he could not find enough scientific evidence to determine whether abortion has harmful psychological effects on women.


Koop maintained his personal opposition to abortion, however. After he left office, he told medical students it violated their Hippocratic oath. In 2009, he wrote to Senate Majority Leader Harry Reid, urging that health care legislation include a provision to ensure doctors and medical students would not be forced to perform abortions. The letter briefly set off a security scare because it was hand delivered.


Koop served as chairman of the National Safe Kids Campaign and as an adviser to President Bill Clinton's health care reform plan.


At a congressional hearing in 2007, Koop spoke about political pressure on the surgeon general post. He said Reagan was pressed to fire him every day, but Reagan would not interfere.


Koop, worried that medicine had lost old-fashioned caring and personal relationships between doctors and patients, opened his institute at Dartmouth to teach medical students basic values and ethics. He also was a part-owner of a short-lived venture, drkoop.com, to provide consumer health care information via the Internet.


Koop was born in the New York City borough of Brooklyn, the only son of a Manhattan banker and the nephew of a doctor. He said by age 5 he knew he wanted to be a surgeon and at age 13 he practiced his skills on neighborhood cats.


He attended Dartmouth, where he received the nickname Chick, short for "chicken Koop." It stuck for life.


Koop received his medical degree at Cornell Medical College, choosing pediatric surgery because so few surgeons practiced it.


In 1938, he married Elizabeth Flanagan, the daughter of a Connecticut doctor. They had four children — Allen, Norman, David and Elizabeth. David, their youngest son, was killed in a mountain climbing accident when he was 20.


Koop was appointed surgeon-in-chief at Children's Hospital in Philadelphia and served as a professor at the University of Pennsylvania School of Medicine.


He pioneered surgery on newborns and successfully separated three sets of conjoined twins. He won national acclaim by reconstructing the chest of a baby born with the heart outside the body.


Although raised as a Baptist, he was drawn to a Presbyterian church near the hospital, where he developed an abiding faith. He began praying at the bedside of his young patients — ignoring the snickers of some of his colleagues.


Koop's wife died in 2007, and he married Cora Hogue in 2010.


He was by far the best-known surgeon general, and for decades afterward was still a recognized personality.


"I was walking down the street with him one time" about five years ago, recalled Dr. George Wohlreich, director of the College of Physicians of Philadelphia, a medical society with which Koop had longstanding ties. "People were yelling out, 'There goes Dr. Koop!' You'd have thought he was a rock star."


___


Ring reported from Montpelier, Vt. Cass reported from Washington. AP Medical Writer Lauran Neergaard in Washington contributed to this report.


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Cops wear face masks due to TB outbreak in downtown L.A.




Los Angeles police over the weekend warned officers who patrol the skid row area to wear protective masks and minimize face-to-face contact with suspects or the public if there is reason to believe that they are infected with tuberculosis.


The warning, contained in an internal communication to officers and employees in the department's Central Division, comes after The Times reported that public health officials have launched a new, coordinated effort to contain what they are calling the largest TB outbreak in a decade.


The Centers for Disease Control and Prevention have dispatched scientists to
Los Angeles to help local health officials gain a better understanding why TB is
spreading and strategies on how to stop it.


Public health officials are searching for more than 4,500 people who may have been exposed to
the disease. In all, nearly 80 tuberculosis cases have been identified and 11 people have died since
2007, most of them homeless people who live in and around skid row.


Scientists have recently linked the outbreak to a tuberculosis strain
that is unique to Los Angeles, with a few isolated cases outside the
area.


Tuberculosis is easily passed along. It is contracted by inhaling droplets
from infected patients when they sneeze, cough or laugh. When left untreated,
the disease can be deadly. The skid row strain can be treated by all anti-TB
medications. Treatment lasts six to nine months. 


LAPD officers who patrol the area have long been warned to be on the lookout for people on the street who exhibit symptoms of communicable diseases which include Hepatitis to HIV and staph infections to drug-resistant TB. Officers must also contend with individuals who have parasitic conditions like scabies and lice.






While noting that risk to law enforcement from TB is "very small," the internal communique nonetheless warns employees to take precautions to reduce the chance of exposure.


"If you have reason to believe that you have been exposed to
a person with TB, notify a supervisor immediately," the email from Capt. Michael Oreb said. "MSD [The City's Medical Services Division] will test any
employee who has been occupationally exposed."


The email also recommends that officers carry protective masks them with them into the field and don them "if officers have reason to believe an individual is infected with TB."


Capt. Horace Frank, commanding officer of Central Division, would not comment specifically on the email but said the issue had been brought up in roll calls.


"Keep in mind that we’ve always stressed to our officers the importance of proper hygiene and conducting business in a safe and healthy manner," Frank said. "This is just a reminder for us to continue exercising the same precautions which we’ve exercised in the past. The key is
that we continue to go about doing the job we have sworn to do, which is to protect and
serve the public."


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 -- Andrew Blankstein


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